IMCBio International PhD Program

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The Integrative Molecular and Cellular Biology (IMCBio) graduate school wishes to attract talented PhD students to the University of Strasbourg to start innovative research projects in 2019. The IMCBio graduate school builds on the strong research developed in four research institutes: IGBMC, IBMC, IBMP and GMGM , which covers all areas of molecular and cellular biology at the levels of molecular factors, genes, cells and organisms from model systems to diseases.

Networking teams of these four Institutes, three Laboratories of Excellence (LabEx), INRT (Integrative biology: Nuclear dynamics, Regenerative and Translational medicine), MitoCross (Mitochondria-nucleus Cross-talk) and NetRNA (Networks of regulatory RNAs) provide a unique opportunity to get a broad overview of every aspects of gene regulation covering nuclear organization, epigenetics, transcriptional, translational, post-transcriptional and post-translational events as well as crosstalks between the nucleus, cytoplasm and organelles in eukaryotes and cell-to-cell communication.

The training community of IMCBio PhD students builds on the expertise of LabEx researchers working in synergy. Trainees also benefit from outstanding technology infrastructure and platforms to develop high-level research projects in a stimulating and interdisciplinary environment. If you are a highly motivated applicant of academic excellence and if you want to start an innovative research project in 2019, then register down below to candidate and join the IMCBio graduate school!
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LabEx INRT

Development and Stem Cells

PhD 2019-1 SAC potentiation strategy in cancer treatment

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Cell cycle and ubiquitin signaling

Team leader: Izabela Sumara

PhD 2019-2 Cells auto-organisations in 3D

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Cell Physics

Team leader: Daniel Riveline

PhD 2019-3 Dissecting the molecular mechanisms of immunoglobulin class switch recombination using CRISPR/Cas9.

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team : Molecular Biology of B cells

Team leader: Bernardo Reina San Martin

PhD 2019-4 Lysosomal pathways and type 2 diabetes

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Signal transduction in metabolism and inflammation

Team leader: Roméo Ricci

Functional Genomics and Cancer

PhD 2019-9 Transcriptional control of hematopoietic stem cell function during aging

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Hematopoiesis and Leukemogenesis

Team leader: Philippe Kastner and Susan Chan

PhD 2019-5 Immune response in cutaneous melanoma microenvironment

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Pathogenesis of Inflammatory Diseases

Team leader: Mei Li

PhD 2019-6 Deciphering a mechanism coupling translation and RNA decay in eukaryotes

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Protein networks and complexes regulating eukaryotic mRNA decay

Team leader: Bertrand Séraphin

PhD 2019-7 Uncovering the molecular mechanisms by which the coregulators of the retinoic acid receptors control male germ cell differentiation

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Retinoic acid signaling pathways driving stem spermatogonia ontogenesis and differentiation

Team leader: Norbert Ghyselynck and Manuel Mark

PhD 2019- 8 In silico analysis of the determinants of functional chromatin loops

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Spatial organization of the genome

Team leader: Tom Sexton

Integrated Structural Biology

PhD 2019-10 Regulation of TBP interactions with promoter DNA

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Architecture of nucleoprotein systems by 3D electron microscopy

Team leader: Patrick Schultz

PhD 2019-11 Structural and functional studies of retroviral Pre-integration complexes

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team : Chromatin stability and DNA mobility

Team leader: Marc Ruff and Valérie Lamour

PhD 2019-12 Structural basis for the inhibition of the eukaryotic ribosome by anticancer drugs

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Molecular Basis for Protein Synthesis by the Ribosome

Team leader: Gulnara Yusupova

PhD 2019-13 Structural and functional studies of Protein Arginine methyltransferases 9 and its complexes with epigenetic coregulators

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Structural biology of epigenetics targets

Team leader: Jean Cavarelli

PhD 2019-14 Structural investigations on Rea1 complexes

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Structural Biology of Molecular Machines

Team leader  Helgo Schmidt

Translational Medecine and Neurogenetics

PhD 2019-15 Development of therapeutic strategy for dominant ataxias caused by polyglutamine expansion

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Fundamental and pathophysiological mechanisms implicated in ataxias

Team leader: Hélène Puccio

PhD 2019-16 Autism Genes and Gastrointestinal Defects: Functional Studies in Danio rerio

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Genetic architecture of autism spectrum disorders and their comorbidities

Team leader: Christelle Golzio

PhD 2019-17 Characterization of the roles of three RNA binding proteins, involved in posttranscriptional regulation and mutated in patients with neurodevelopmental disorders, in neuronal cells

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Genetics and pathophysiology of neurodevelopmental and Epileptogenic Disorders

Team leader: Jamel Chelly

PhD 2019-18 Regulation of diacylglycerol kinase by FMRP and its dysregulation in Fragile X syndrome

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team  Genetics and pathophysiology of neurodevelopmental and Epileptogenic Disorders

Team leader: Jamel Chelly

PhD 2019-19 Validation of novel therapies for severe congenital myopathies

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Pathophysiology of neuromuscular diseases

Team leader: Jocelyn Laporte

PhD 2019-20 Dyrk1a in retinal development and function

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Physiopathology of aneuploidy, gene dosage effect and Down syndrome

Team leader: Yann Hérault

PhD 2019-21 Transfer RNA, key drivers of neuronal fate acquisition?

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team: Regulation of cortical development in health and disease

Team leader: Juliette Godin

LabEx INRT / LabEx NetRNA

INRT Functional Genomics and Cancer / NetRNA

PhD 2019-22 Unraveling the “inflammatory-chromatin” epigenetic code using Drosophila genetics

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team 1: Immune and neural development

Team leader 1: Angela Giangrande

Modèles insectes d'immunité innée - M3I

Team 2: Genetic of the immune response

Team leader 2: Nicolas Matt

INRT Integrated Structural Biology / NetRNA

PhD 2019-23 Translational control in Staphylococcus aureus at high resolution: role of rRNA and tRNA modifications

Architecture et Réactivité de l'ARN - ARN

Team 1: mRNAs and regulatory RNAs in bacteria

Team leader 1: Pascale Romby

Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC

Team 2: Large complexes involved in gene expression regulation

Team leader 2: Bruno Klaholz

LabEx MitoCross / LabEx NetRNA

PhD 2019-24 Characterization of the mitochondrial import and function of mammalian Argonaute 2 protein

Génétique Moléculaire, Génomique, Microbiologie - GMGM

Team 1: Dynamic and plasticity of the synthetases

Team leader 1: Hubert Becker, hbecker@unistra.fr, +33 3 68 85 14 70

Architecture et Réactivité de l'ARN - ARN

Team 2: Non coding RNAs and viral infection

Team leader 2: Sébastien Pfeffer, spfeffer@unistra.fr, +33 3 88 41 70 60

PhD 2019-25 Exploring the functional and structural diversity of NYN domain ribonucleases

Institut de Biologie Moléculaire des Plantes - IBMP

Team 1: Functions of PPR proteins

Team leader 1: Philippe Giegé

Architecture et Réactivité de l'ARN - ARN

Team 2: Biology of tRNA and pathogenicity

Team leader 2: Magali Frugier